@melann77 I used to MN at 0.25 depth once a week for some time but medical MN was just giving better results so I skipped it. Yes, it's good for getting the product in the skin. Nano's a bit different as the number of needles varies and its more like a stamp method. I haven't used nano cartridges for MN at 0.25, I used 42 pin cartrige instead.